p15 Expression Differentiates Nevus from Melanoma
نویسندگان
چکیده
منابع مشابه
In Situ Antigen Expression on Melanoma and Nevus
The hypothesis that cells become malignant through a multistep process has been developed from studies on chemically induced tumors (1) and is supported by the demonstrat ion that multiple oncogenes are required to induce malignancy in vitro (2). Malignant melanoma is a spontaneous human tumor in which clinical and histopathologicai criteria can be used to define a series of proliferative lesio...
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UNLABELLED Deletion of the entire CDKN2B-CDKN2A gene cluster is among the most common genetic events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A-encoded p16 and p14ARF tumor suppressors. The degree to which the associated CDKN2B-encoded p15 loss contributes to human tumorigenesis is unclear. Here, we show that CDKN2B is highly upregulated in benign melanocy...
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The association of melanoma with a preexisting melanocytic nevus varies considerably between series, depending on whether the association is based on histological signs (4%-72%) or a clinically evident lesion (42%-85%). Histological association with a nevus correlates with favorable prognostic factors, whereas a clinical association correlates with unfavorable factors. In this review, we discus...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2016
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2016.08.009